Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism
نویسندگان
چکیده
منابع مشابه
Response to levodopa in parkinsonian patients with bilateral subthalamic nucleus stimulation.
The response to levodopa changes over time in Parkinson's disease, probably due to alterations in the dopaminergic system, progression of the disease and pulsatile oral intake of the drug. Bilateral high-frequency stimulation of the subthalamic nucleus (STN) allows a large reduction or the complete cessation of levodopa intake in patients with advanced Parkinson's disease. We studied variation ...
متن کاملEffects of subthalamic nucleus stimulation and levodopa treatment on gait abnormalities in Parkinson disease.
BACKGROUND Stimulation of the subthalamic nucleus is proposed for the treatment of patients presenting with severe Parkinson disease. The effect on gait is not clearly established. OBJECTIVES To evaluate objectively the influence of bilateral subthalamic nucleus stimulation on gait in Parkinson disease and to compare it with the effects of levodopa treatment. METHODS Ten patients underwent ...
متن کاملDeep brain stimulation of the subthalamic nucleus for peripherally induced parkinsonism.
RESULTS Trauma to the peripheral nervous system can cause various movement disorders including dystonia, tremor and parkinsonism. Most patients with peripherally-induced parkinsonism develop symptoms that extend beyond the original site of injury, suggesting involvement of the central nervous system, possibly through reorganization in response to altered peripheral input. Most patients with per...
متن کاملStimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism.
Deep brain stimulation (DBS) has an increasing role in the treatment of idiopathic Parkinson's disease. Although, the subthalamic nucleus (STN) is the commonly chosen target, a number of groups have reported that the most effective contact lies dorsal/dorsomedial to the STN (region of the pallidofugal fibres and the rostral zona incerta) or at the junction between the dorsal border of the STN a...
متن کاملLevodopa and subthalamic deep brain stimulation responses are not congruent.
There is a consensus that in Parkinson's disease, the extent of preoperative levodopa responsiveness predicts the efficacy of subthalamic nucleus deep brain stimulation (STN DBS). However, this may be the result of statistical methods and primary assumptions. We were able to reproduce previously published correlation results on our data (N = 49 patients). Yet, these same results were demonstrat...
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ژورنال
عنوان ژورنال: Neurology
سال: 2000
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.54.11.2182